A struggling film director at an existential crossroads takes his life, but is reborn as his muse and forced to face the decisions and relationships that inspired his work. In self-reflexive scenes, the character-actors in Killing the Muse explore the art of filmmaking, sexuality, and their personal circumstances. How much does their art reflect their personal lives? Where and what are the boundaries of each? Killing the Muse proves to be intriguing and engrossing, mind-bending, and often funny.